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Researchers from the
University of California, San Francisco, assessed a new
indicator of kidney function -- called "cystatin C" -- in more
than 3,000 people ages 70 to 79. Researchers evaluated "cystatin
C" levels as a way to predict the risk of death over a
six-year follow up period. Results of the study show the
higher the "cystatin C" level, the higher the risk of death.
The risk of death was 1.7 percent a year for people with the
lowest "cystatin C" levels, while it was 5.4 percent per year
for the people with the highest levels. Even after adjusting
for the presence of other diseases and risk factors, the risk
of death was more than twice as high among people with the
highest "cystatin C" levels as compared to those with the
lowest levels. The risk was similar between men and women and
between blacks and whites. Researchers say "cystatin C" levels
were a significant predictor of death from heart disease, but
were not linked to the risk of death from cancer. In older
people, reduced kidney function is linked to a decreased life
expectancy. "Cystatin C" is a fairly new kidney function
indicator that seems to be a better predictor of kidney
function than the standard test used. The standard test for
kidney function is the serum creatinine level. Results from a
creatinine test, however, can be influenced by everything from
age and weight to sex and race. The "cystatin C" level test is
not affected by those factors. Researchers say it may also be
more sensitive in detecting small changes in kidney function.
Authors of the study conclude, "Cystatin C is a strong,
independent risk factor for mortality in the elderly.
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