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Healthcare online Keeping you up-to-date
VOL.  5     ISSUE:  12    December 17, 2007 Medical Services Department

SQUARE Pharmaceuticals Ltd.

EDITORIAL

Dear Doctor:

Welcome to this edition of 'e-SQUARE' . Hope you are enjoying this online healthcare bulletin.

Our current issue focused on some interesting features like

"Smoking And Hair !", "Vein Viewer !", "Fish Helps Memory ! "Vitamin-D" curbs Diabetes !", "Blood Pressure Vaccine !", "Depression And Heart Risk !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,

 

Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE PHARMACEUTICALS LTD.

 Smoking And Hair !

 Smoking May Cause Hair Thinning

A study conducted among Asian men shows smoking increases the risk for hair loss. Investigators from Taiwan looked at a type of hair loss called androgenetic alopecia in 740 middle aged and older men. Androgenetic alopecia is the most common form of hair loss in men and is generally considered to be hereditary. But environmental factors may also come into play, and the researchers decided to explain how smoking status would affect the condition. All the men were surveyed during in-person interviews about their risk for androgenetic alopecia, when they first began losing their hair, and smoking status. Age was a major predictor of hair loss, but results also showed men who smoked were significantly more likely to have the condition, especially if they reported smoking 20 or more cigarettes a day. The investigators speculate smoking may increase the risk for hair loss by either destroying hair follicles or damaging bodily functions responsible for maintaining a healthy head of hair.

 

SOURCE: Archives of Dermatology, 2007

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 Vein Viewer !

Easier Blood Draws

It's one of the bigger challenges for health care workers – finding a good vein in hard-to-stick patients like children, the elderly or tiny babies. A new device is bringing less pain to the process with a glowing look below the skin. The device -- called a VeinViewer -- brings veins out of hiding by shining a green light on the skin -- revealing blood vessels as black lines. The device uses near-infrared light that reflects hemoglobin, which is blood, so that way one can see the veins and can not seeing tendons or anything else, says the researcher. It’s primary role at hospitals is to spare patients from unnecessary pain as well as it can save money by taking less time and using fewer materials. 

 

SOURCE: Ivanhoe Newswire, 2007

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 Fish Helps Memory !

More Fish Intake May Improve Senior's Memory

Researchers found that elderly men and women who more frequently ate fish scored better on memory, visual conception, spatial motor skills, attention, orientation, and verbal fluency tests. The lead researcher said that all six cognitive tests were performed better by those who ate fish. Furthermore, the effect was stronger as fish consumption increased up to a limit of about 80 grams per day, he added. They assessed cognitive ability and the average daily amount of fish and seafood in the diets of 2,031 men and women, between 70 and 74 years old, recruited from the general population of Western Norway. Overall, 1,951 of the study participants reported eating 10 or more grams per day of fresh, frozen, or canned fish and seafood, or fish products such as cod liver and fish oil, the investigators report. The remaining 80 participants ate less than 10 grams daily. Study participants who reported more frequent consumption of fatty or lean fish as their main meal performed significantly better in five of the six cognitive tests, compared with those who did not eat fatty or lean fish.  By contrast, seniors who consumed only fish oils performed better on just one of the tests. Additional research need to determine whether the cognitive benefits from fish and seafood consumption depend on the type, the species of fish or on the preparation.

 

SOURCE: American Journal of Clinical Nutrition, 2007

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 "Vitamin-D" Curbs Diabetes !

Vitamin D May Cut Risk Of Type 2 Diabetes

During a 17-year follow-up of roughly 4,000 men and women, researchers found that individuals with higher blood levels of vitamin D had a 40 percent lower risk of developing type 2 diabetes than those with lower levels of this vitamin. During study period, 187 people developed type 2 diabetes. After adjusting for age, sex, and month when blood samples were obtained, a statistically significant inverse association was observed between the blood vitamin D level and the development of type 2 diabetes. People with the highest vitamin D levels had a 40 percent lower risk of developing type 2 diabetes as those with the lowest vitamin D levels, the researcher said. This association was attenuated somewhat after further adjustments were made for potential risk factors for type 2 diabetes, including body weight, physical activity level, and smoking.

 

SOURCE: Diabetes Care, 2007

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 Blood Pressure Vaccine !

Blood Pressure Vaccine Shows Promise

Researchers revealed a vaccine that would obviate the need to take anti-hypertensive drugs every day. This new vaccine, known as CYT006-AngQb, works by inhibiting angiotensin II, a molecule that constricts blood vessels and raises blood pressure. Several existing medications target the same molecule, including ACE (angiotensin-converting enzyme) inhibitors and ARBs (angiotensin receptor blockers). For this trial, 72 volunteers with mild to moderate high blood pressure were injected with 100 or 300 micrograms (ug) of the vaccine or a placebo at zero, four and 12 weeks from the start of the trial. Volunteers included 65 men and seven women, average age 51.5 years. Patients who received either dose of the vaccine produced antibodies against angiotensin II after the first injection. The response was significantly higher in those who received the higher dose and was also relatively longer-lived. After 14 weeks, systolic blood pressure in the high-dose group was reduced by 5.6 mm Hg and diastolic blood pressure fell by 2.8 mm Hg. And there was another, unexpected benefit: The vaccine appeared to dampen the typical blood pressure surge that occurs between 5 a.m. and 8 a.m., lowering systolic blood pressure by 25 mm Hg and diastolic blood pressure by 13 mm Hg in that time period. The wee hours of the morning are the most dangerous time to have high blood pressure as it raises the risk of heart attack and stroke, experts noted. The vaccine needs further testing, especially to see if the body would be allowed any "escape mechanism" that would allow it to raise blood pressure if and when needed.

 

SOURCE: HealthDay, 2007

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 Depression And Heart Risk

“Depression” At Any Point In Life Tied To Heart Risk

New research suggests that older adults who've suffered a bout of major depression at any time in their lives appear to face an elevated risk of heart disease. In a study of more than 10,000 U.S. adults ages 60 or older, researchers found that those who ever had an episode of major depression were more than twice as likely as those without such a history to have coronary heart disease. The link remained when the researchers accounted for other factors related to mental health and heart health -- such as obesity, smoking, drug use and high blood pressure. For people with a history of major depression, the findings suggest that early and regular check-ups for their heart health might be wise. Managing other heart risk factors -- by lowering blood pressure, quitting smoking or making diet and exercise changes, for example -- may help counter the heightened risk. The findings are based on data from a national health survey of 10,573 older U.S. adults. Participants completed a standard questionnaire used to diagnose major depression and certain other mood disorders. Men and women with a single lifetime episode of major depression had a risk of heart disease comparable to that of participants who'd suffered multiple bouts of depression, a "noteworthy" finding, according to the researcher. Experts suspect that depression may affect heart disease risk through direct physiological effects. For example, research suggests that depression boosts the activity of platelets. It may also have effects on the immune system or the sympathetic and parasympathetic nervous systems, which help regulate the heart's response to everyday stresses.

 

SOURCE: MedlinePlus, 2007

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New Products of SQUARE Pharmaceuticals Ltd.

  Product Lerozole®
  Generic Name Letrozole USP
  Strength 2.5 mg
  Dosage form Tablet
  Therapeutic Category Cytostatic Aromatase Inhibitor
  Product Ripril Plus® 5/25
Generic Name

Ramipril BP + Hydrochlorthiazide BP

Strength

5 mg + 25 mg

Dosage form Tablet
Therapeutic Category ACE Inhibitor Combination
  Product Osiden®
  Generic Name Adenosine BP
  Strength

6 mg/2 ml

  Dosage form Injection
  Therapeutic Category Antiarrhythmic

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