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Healthcare online Keeping you up-to-date
VOL.  7     ISSUE:  5    May 28, 2009 Medical Services Department

SQUARE Pharmaceuticals Ltd.

EDITORIAL

Dear Doctor:

Welcome to this edition of 'e-SQUARE' . Hope you are enjoying this online healthcare bulletin.

Our current issue focused on some interesting features like

"Dialysis Risk !", "Obesity And Asthma !", "Cervical Cancer Risk !", "Fenofibrate Alert !", "Vitamin D Alert !", "Folic Acid & Heart Defect !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,

 

Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE PHARMACEUTICALS LTD.

 Dialysis Risk !

Drug Combination Reduces Risk Of Dialysis Failure

A new drug combination may keep grafts working better for dialysis patients and boost their chances at a healthier life. For the first time, a combination of aspirin and the anti-platelet drug dipyridamole have been shown to significantly increase a dialysis patient's risk of dialysis access failure. The researchers found that the combination treatment decreased the rate of loss of primary unassisted graft patency (the useful life of a graft before it's blocked for the first time) by 18 percent and the rate of developing significant stenosis by 28 percent. Arteriovenous grafts (AV) grafts, fail most often due to stenosis at the graft site and subsequent clotting, which blocks the flow of blood. A blocked graft cannot be used for dialysis and is a major cause of worsening health in dialysis patients. “The trial results show that now there is a drug therapy that significantly prolongs the viability of AV grafts," according to the lead author of the University of Iowa College of Medicine, Iowa City. This is an important step forward as the researchers proceed to develop therapies to improve dialysis patients' quality of life.

SOURCE: New England Journal of Medicine, May 2009.

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 Obesity And Asthma !

Mother’s Obesity Linked To Asthma In Kids

Obese women are more likely to end up with children who have asthma. This finding comes from researchers in The Netherlands who followed nearly 4,000 children from before birth up to age eight. About 20 percent of their mothers were overweight, and among children with at least one parent with asthma, having an obese mother increased the risk of asthma by age eight by 65 percent. The researchers explain excess fat produces pro-inflammatory cytokines and suppresses anti-inflammatory cytokines. Cytokines are known to play a role in asthma. “Therefore, in an obese person, it is not just a problem of excess fat, but a problem of systemic inflammation,” the study author said. “This may affect the immunological and pulmonary development in the fetus and possibly result in a higher risk of asthma symptoms after birth.” The researcher believes the findings of his study should provide one more reason for women in their childbearing years to maintain a healthy weight – or lose weight, if they are already overweight or obese.

SOURCE: Ivanhoe Newswire, May 2009.

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 Cervical Cancer Risk !

Condition Puts Women At Risk For Cervical Cancer

Women treated for “cervical intraepithelial neoplasia (CIN)” have a higher risk for developing invasive cervical cancer. CIN is the abnormal growth of cells on the surface of the cervix. According to the article, information on the long-term risks among women previously treated for the condition is limited. Researchers studied more than 37,000 women who were treated for CIN between 1986 and 2000. They compared them to a group of more than 71,000 women who were not diagnosed with CIN. Study results show the overall incidence of cervical cancer in the CIN group was 37 cervical cancers per 100,000 women. The incidence of cervical cancer in the group without CIN was 06 cancers per 100,000 women. The researchers also found the risk for cervical cancer or another diagnosis of CIN was associated with age, the severity of the condition, and treatment type. The risk of invasive cancer and a CIN recurrence was highest for women who were older than 40 years, were previously treated for CIN 3, or were treated with cryotherapy.

SOURCE: Ivanhoe Newswire, May 2009.

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 Fenofibrate Alert !

Drug May Lessen Amputation Risk For Diabetics

The chances of having to have a limb amputated because of diabetes were reduced by 36 percent when people with type 2 diabetes were given the drug fenofibrate to lower their blood fat levels, new research has found. The study included 9,795 people, ages 50 to 75, who took either 200 milligrams of fenofibrate or a placebo daily for five years. The researchers reported that 115 people had lower-limb amputations attributed to diabetes. People with previous cardiovascular disease, microvascular disease, previous non-traumatic amputation or skin ulcer, smoking and a longer duration of diabetes were more likely to have amputations than those who had other cardiovascular problems or those who had neither cardiovascular issues or amputations. The risk of a first amputation was 36 percent lower among people taking fenofibrate than those taking the placebo. The study also found that people in the fenofibrate group had a 47 percent lower risk of amputations below the ankle and without large-vessel disease in the amputated limb. The researchers considered the status of large-vessel disease to distinguish amputations related to large-artery atherosclerosis from those related to diabetic microvascular disease. The study found virtually no difference in the risk for amputations above the ankle between those who did and did not take fenofibrate. "These findings could lead to a change in standard treatment for the prevention of diabetes-related lower-limb amputations," concluded by a professor of the National Health and Medical Research Council Clinical Trials Centre at the University of Sydney, in Australia, and his colleagues.

SOURCE: HealthDay News, May 2009.

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 Vitamin D Alert !

Vitamin D May Lessen Decline In Mental Agility

Getting more of the "Sunshine vitamin" may make one brighter later in life, according to a study that bolsters evidence vitamin D may help older people stay mentally fit. The findings also raise the prospect that people who do not get enough of the vitamin could use supplements to keep the brain fully functioning as they age, according to the researchers at the University of Manchester. Vitamin D, produced by the body when skin is exposed to sunlight, is also found in certain foods such as oily fish. It helps cells absorb calcium and is important for bone health. Recent studies have also indicated vitamin D may protect against cancer, artery disease and tuberculosis. The researchers compared the cognitive performance of more than 3,000 European men aged 40 to 79 and found those with low vitamin D levels did more poorly on a task designed to test mental agility. The findings are some of the strongest evidence yet of such a link because of the size of the study and because the researchers adjusted for a number of lifestyle factors believed to affect mental ability when older, the scientist said. The researchers were able to take into account their educational level, their depression, their levels of physical activity and measures of physical performance. The researchers do not know exactly how vitamin D and mental agility may be connected but said possible suggestions include the vitamin's role in increasing certain hormonal activity or the protection of neurons in the brain. They also stressed their findings should not spur people to bask in the sun, which can increase the risk of skin cancer.

SOURCE: Reuters Health, May 2009.

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 Folic Acid & Heart Defect !

Folic Acid Reduces Infant Heart Defects

Since the mandatory addition of folic acid to flour, pasta and other grain products took effect in Canada more than a decade ago, fewer babies have been born with congenital heart defects, researchers report. Folic acid, a type of vitamin B, has been shown to reduce neural tube birth defects, such as spina bifida or anencephaly. Now it seems folic acid may also prevent heart defects. In the United States, the Food and Drug Administration in 1996 required that folic acid be added to enriched breads, cereals, flours, corn meals, pastas, rice and other grain products. By 2004, the number of infants born with spina bifida or anencephaly had dropped 26 percent, according to the U.S. Centers for Disease Control and Prevention. In Quebec, flour and pasta have been fortified with folic acid since 1998. In this study, a team at McGill University in Montreal collected data on 1.3 million births in Quebec from 1990 to 2005. During that period 2,083 children were born with heart defects, an average of 1.57 for every 1,000 births. The researchers found a 6 percent decrease in heart defects each year after folic acid was added to grain products. In another study reported this year, folic acid intake was shown to reduce the likelihood of premature birth. Despite a Canadian awareness campaign launched in 2002, many mothers still do not take folic acid supplements before becoming pregnant, the Quebec study noted. "Women at conceptual age should be aware of the preventive effects of folic acid and take it before becoming pregnant," the researcher added.

SOURCE: HealthDay  News, May 2009.

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New Products of SQUARE Pharmaceuticals Ltd.

  Product Anoxa®
  Generic Name Oxazepam BP
  Strength 10 mg
  Dosage form Tablet
  Therapeutic Category Anxiolytic
  Product Evit Licap®
Generic Name

Vitamin E

Strength

200 mg

Dosage form Licap
Therapeutic Category Vitamin E Plain
  Product Peuritar®
  Generic Name Sodium Dichloroisocyanurate
  Strength

Peuritar 1(17 mg), Peuritar 3 (51 mg)

  Dosage form Effervescent Tablet
  Therapeutic Category Water purifier

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