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Healthcare online Keeping you up-to-date
VOL.  7     ISSUE:  6    June 30, 2009 Medical Services Department

SQUARE Pharmaceuticals Ltd.

Features

EDITORIAL TEAM

OMAR AKRAMUR RAB

MBBS, FCGP, FIAGP,

P G Dip. Business Management

MAHFUZUR RAHMAN, MBBS

 

EDITORIAL

Dear Doctor,

Welcome to this edition of 'e-SQUARE'. Hope you are enjoying this online healthcare bulletin.

Our current issue focused on some interesting features like -

"HIV-AIDS Alert !", "Green Tea & Cancer !", "Omega - 3 & Macular Disease !", "New Biomarker !",  "Longevity Food !", "Cell Phone Elbow !".

In our regular feature, we have some products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,

 

Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE Pharmaceuticals Ltd.

 HIV-AIDS Alert !

Powerful New Weapon Against HIV-AIDS

A new study indicates that a radical new therapy would make it possible to destroy the HIV-AIDS viruses circulating in the body as well as those playing hide-and-seek in the immune system. The treatment involves a combination of targeted chemotherapy and current Highly Active Retroviral (HAART) treatments. To date, anti-AIDS treatments have been stymied by "HIV reservoirs" – immune system cells in which the virus hides and which existing HAART treatments cannot reach. Researchers have successfully identified cells where HIV hides and the "stealth" mechanisms that allow the virus to escape existing treatments. This breakthrough opens the way to innovative therapies that are completely different from current approaches. Researchers of the Université de Montréal, the Research Institute of the McGill University Health Centre (RI-MUHC) and scientists from the National Institutes of Health (NIH) and the University of Minnesota in the US also collaborated on the investigation. The researcher said that their results argue in favor of a strategy similar to the one used against leukemia which is targeted chemotherapy associated with a targeted immune treatment. This would make it possible to destroy the cells containing a virus, while giving the immune system time to regenerate with healthy cells. "For the first time, this study proves that the HIV reservoirs are not due to a lack of potency of the antiretroviral drugs, but to the virus hiding inside two different types of long-life CD4 memory immune cells," according to the scientist. "There are several types of HIV reservoirs, each necessitating a different treatment to eliminate them," he added. Existing HAART treatments destroy the viruses circulating in the body, yet cannot reach those hidden in reservoir cells. Indeed, once the virus is hidden in these reservoir cells, it becomes dependent upon them, researchers explained. If the cell lives, the virus lives, but if the cell dies, so does the virus. As such, destroying these immune cells will allow for the elimination of the resilient or hidden parts of the virus. "The combination of fundamental and clinical approaches led to amazing results that allow us to elucidate another mystery of this virus of a thousand faces," the researcher concluded.

SOURCE: Ivanhoe Newswire, June 2009

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 Green Tea & Cancer !

Green Tea: The Future Cancer Therapy

According to a recent study, men with prostate cancer who consumed the active compounds in green tea demonstrated a significant reduction in serum markers predictive of prostate cancer progression. "The investigational agent used in the trial, Polyphenon E, may have the potential to lower the incidence and slow the progression of prostate cancer," according to the researchers at the Feist-Weiller Cancer Center, LSU Health Sciences Center-Shreveport, LA. Few studies to date have evaluated the change in biomarkers, which might predict disease progression. The scientists conducted this open-label, single-arm, phase II clinical trial to determine the effects of short-term supplementation with green tea's active compounds on serum biomarkers in patients with prostate cancer. The biomarkers include hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and prostate specific antigen (PSA). HGF and VEGF are good prognostic indicators of metastatic disease. The study included 26 men, aged 41 to 72 years, diagnosed with prostate cancer and scheduled for radical prostatectomy. Patients consumed four capsules containing Polyphenon E until the day before surgery — four capsules are equivalent to about 12 cups of normally brewed concentrated green tea. The time of study for 25 of the 26 patients ranged from 12 days to 73 days. Findings showed a significant reduction in serum levels of HGF, VEGF and PSA after treatment, with some patients demonstrating reductions in levels of greater than 30 percent, according to the researchers.  There were only a few reported side effects associated with this study, and liver function remained normal. Results of a recent year-long clinical trial conduced by researchers in Italy demonstrated that consumption of green tea polyphenols reduced the risk of developing prostate cancer in men with high-grade prostate intraepithelial neoplasia (HGPIN). "These studies are just the beginning and a lot of work remains to be done; however, we think that the use of tea polyphenols alone or in combination with other compounds currently used for cancer therapy should be explored as an approach to prevent cancer progression and recurrence," the scientist added.

SOURCE: Ivanhoe Newswire, June 2009

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 Omega – 3 & Macular Disease !

Omega-3-Fatty Acids Could Slow Macular Disease

Diets rich in omega-3-fatty acids may slow the progression of early age-related macular degeneration to advanced disease, according to a report in the British Journal of Ophthalmology. Age-related macular degeneration is an eye disorder that affects the macula, the part of the retina responsible for central vision, and is primarily seen in patients older than 60 years. The findings are based on an analysis of data from 2924 subjects who were enrolled in the Age-Related Eye Disease Study (AREDS) and were randomly assigned to receive one of four dietary supplement groups: placebo, antioxidants, zinc, or antioxidants plus zinc. As part of AREDS, the subjects completed food frequency questionnaires at the beginning of the study and underwent periodic general and ophthalmologic physical examinations, the researcher from Tufts University, Boston, and co-researchers explain. The authors found that regardless of which supplement was given, higher quantities of omega fatty acids lowered the risk of progression to advanced macular degeneration. In addition, a lower dietary glycemic index correlated with a 24 percent reduced risk of progression. "The present study adds additional support to the idea that diet and, if necessary, supplementation can be optimized for the prevention of acute macular degeneration," the researchers conclude.

SOURCE: Reuters Health, June 2009

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 New Biomarker !

 Urine Test For Appendicitis

Diagnosing appendicitis, the most common childhood surgical emergency, can be challenging, especially in children. A missed diagnosis can lead to unnecessary surgery in children without appendicitis or to a ruptured appendix and serious complications when the condition is missed. Now, emergency medicine physicians and scientists at the Proteomics Center at Children's Hospital Boston demonstrate that a protein detectable in urine might serve as a "biomarker" for appendicitis. Despite improvement in imaging technologies, recent figures indicate that 3 to 30 percent of children have unnecessary appendectomies, while 30 to 45 percent of those diagnosed with appendicitis already have a ruptured appendix. Laboratory biomarkers have been identified, but none have proved reliable enough to be clinically useful. Researchers of emergency medicine at Children's Hospital Boston, decided to take a systematic approach, performing a proteomics study using state-of-the are mass spectrometry (a technique that detects and quantifies proteins in a sample). Their two-part study has identified the most accurate biomarker for acute appendicitis known to date. The researchers identified seven promising urine biomarkers. The best of them was leucine-rich alpha-2-glycoprotein (LRG), which appears to be a specific marker of local inflammation. It had an "area under the curve" value of 0.97, indicating near-perfect sensitivity (with almost no false-negatives) and near-perfect specificity (almost no false-positives). LRG was strongly elevated in diseased appendices, even when those appendices appeared normal on imaging. Although mass spectrometry is not widely available clinically, urine LRG elevations were detected by immunoblotting, suggesting that a rapid clinical test, such as a urine dipstick, could be developed through further research. "Recent diagnostic advances have focused on advanced radiologic procedures, such as computed tomography and ultrasound, but these resources are not universally available and can delay diagnosis," the researchers said. "Although these advances have improved the diagnosis and decreased complications from appendicitis, CT scans also expose children to radiation that may increase the lifetime risk of cancer," they added. The researchers further note that since their study was limited to children, patterns of biomarkers likely vary in older patients and LRG testing would need to be studied in other clinical settings.

SOURCE: Ivanhoe Newswire, June 2009

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 Longevity Food !

Mediterranean Foods Promote Longevity

The Mediterranean diet is well known for making people live longer, but new research reveals the individual components of the diet which promote longevity. The researcher at the Harvard School of Public Health surveyed over 23,000 participants on lifestyle and diet. Participants were interviewed over a period of 8.5 years. Researchers found key Mediterranean foods to promote health and a longer life are vegetables, fruits, nuts, pulses, and olive oil. Researchers recommend limiting the amount of meat, and moderating alcohol intake. The study also shows that a diet high in fish, seafood, and cereals, and low in dairy does not necessarily indicate longevity.  

SOURCE: Ivanhoe Newswire, June 2009

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 Cell Phone Elbow !

 'Cell Phone Elbow' -- A New Disorder For The Wired Age

Medically known as cubital tunnel syndrome, cell phone elbow is numbness, tingling and pain in the forearm and hand caused by compression of the ulnar nerve, which passes along the bony bump on the inside of the elbow. Prolonged flexing of the elbow, such as when a cell phone is held to the ear, puts tension on the ulnar nerve. In susceptible people, holding the bent-elbow position for extended periods can lead to decreased blood flow, inflammation and compression of the nerve. "Repetitive, sustained stretching of the nerve is like stepping on a garden hose," said the director of the Cleveland Clinic's Hand and Upper Extremity Center. The first symptoms patients often notice include numbness, tingling or aching in the forearm and hand. As symptoms progress, they can include a loss of muscle strength, coordination and mobility that can make writing and typing difficult. In chronic, untreated cases, the ring finger can become clawed. Though there are no solid figures on how many people have cell phone elbow, hand specialists say the incidence is increasing along with the 3.3 billion cell phone service contracts active worldwide, the researcher said. Still, the disorder is less common than carpal tunnel syndrome, a related condition that causes pain in the hand and wrist. Carpal tunnel syndrome is caused by compression of the median nerve that runs from the forearm into the hand. "Cubital tunnel is the second most common compression syndrome we see," said an occupational therapist and certified hand specialist at William Beaumont Hospital in Royal Oak, Mich. Most people who get cubital tunnel syndrome are middle-aged or older. Women get cubital tunnel syndrome more often than men -- and it's probably not because they talk more. Although the precise reasons are unknown, women may be more susceptible due to hormonal fluctuations or their anatomy, the scientist said. And too much talking isn't the only cause of cubital tunnel syndrome. Other causes may include sleeping with the elbows bent and tucked up into the chest, sitting at a desk with the elbows flexed at an angle greater than 90 degrees and driving with the elbow propped on the window for extended periods, he said. In most cases, minor lifestyle changes can help alleviate symptoms, including using a hands-free headset for cell phone. If sleep position is the problem, an elbow pad to keep the arm straighter at night can help. More serious cases are referred to an occupational therapist, who may use ultrasound to loosen scar tissue that can form around the nerve as a result of the inflammation, as well as stretching, deep massage and "nerve-gliding" exercises to reduce pressure on the nerve, according to the lead scientist. Doctors may also use anti-inflammatory injections or surgery.

SOURCE: HealthDay News, June 2009.

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New Products of SQUARE Pharmaceuticals Ltd.

  Product Cadnyl® 4 Tablet
  Generic Name

Perindopril Erbumine BP

  Strength

4 mg

  Dosage form Film Coated Tablet
  Therapeutic Category ACE inhibitor
  Product Flugal® 200 Capsule
Generic Name Fluconazole USP
Strength

200 mg

Dosage form Capsule
Therapeutic Category Systemic antifungal
  Product Virux® Suspension
  Generic Name Aciclovir
  Strength

200 mg/5 ml

  Dosage form Suspension
  Therapeutic Category Systemic Anti-virals (Excluding Anti-HIV)

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