SQUARE

e-

SQUARE

 
Healthcare online Keeping you up-to-date
VOL.  8     ISSUE:  2    February 2010 Medical Services Department

SQUARE Pharmaceuticals Ltd.

EDITORIAL

Dear Doctor:

Welcome to this edition of 'e-SQUARE' . Hope you are enjoying this online healthcare bulletin.

Our current issue focused on some interesting features like

"Lymph Nodes Removal in Cancer !", "Heart CT & Radiation !", "Migraine & Multiple Sclerosis !", "Chest Pain Test !", "B-Vitamins Helps !", "Overactive Thyroid & Stroke !".

In our regular feature, we have some new products information of SQUARE Pharmaceuticals Ltd. as well.

We will appreciate your feedback !

Click on to reply mode.

Yours sincerely,

 

Editorial Team

Reply Mode      : e-square@squaregroup.com

The views expressed in this publication do not necessarily reflect those of its editor or SQUARE PHARMACEUTICALS LTD.

 Lymph Nodes Removal in Cancer !

 Lymph Nodes Removal May Boost Endometrial Cancer Survival

Endometrial cancer patients at medium to high risk for cancer recurrence are more likely to survive if both the pelvic lymph nodes and para-aortic lymph nodes are removed, rather than just the pelvic lymph nodes, say Japanese researchers. The para-aortic lymph nodes, which are located in front of the lumbar vertebral bodies near the aorta, receive drainage from the lower gastrointestinal tract and the pelvic organs, according to a news release about the study. The study included 671 women with endometrial cancer who had pelvic lymph nodes removed or both pelvic and para-aortic lymph nodes removed. Women at medium or high risk for cancer recurrence were offered additional treatment in the form of chemotherapy or radiotherapy. Those at medium to high risk for recurrence who had both pelvic and para-aortic lymph nodes removed were 56 percent less likely to die than were those who had only their pelvic lymph nodes removed, the study found. The removal of both pelvic and para-aortic lymph nodes was found to have no impact on survival among people at low risk for cancer recurrence. Analysis of 328 medium- to high-risk women who were also treated with radiotherapy or chemotherapy showed that having the complete procedure decreased the risk for dying prematurely by 52 percent, and having just chemotherapy decreased the risk by 41 percent, independently of one another, according to the study of the Hokkaido University Graduate School of Medicine in Sapporo, Japan. The findings show that removal of both pelvic and para-aortic lymph nodes should be recommended for endometrial cancer patients at medium to high risk for recurrence, the researchers concluded, adding that the results suggest that adding chemotherapy could further improve their likelihood of survival.

SOURCE: HealthDay News, February 2010.

Return to top

 Heart CT & Radiation !

New Heart CT Scans Deliver Far Less Radiation: Study

The newest heart imaging CT technology exposes patients to as much as 91 percent less radiation than standard CT scanning, researchers say. "Coronary CT angiography has generated great enthusiasm in recent years, due to its diagnostic accuracy in assessing patients with known or suspected coronary artery disease. However, that enthusiasm has been tempered by concern about the potentially high radiation dose received by patients," according to  an assistant professor of clinical medicine in radiology and director of cardiac CT research at Columbia University Medical Center. The researchers compared radiation exposure with a standard 64-detector row CT scanner -- which can image 4 centimeters of the heart at a time -- and a 320-detector row volume CT scanner, which can image 16 centimeters -- the entire length of the heart -- in a single rotation and within a single heartbeat. "By imaging the entire heart in one piece, volume scanning eliminates artifacts due to seams or gaps between image sections. Moreover, the X-ray tube is left on for only a brief duration, as little as 0.35 seconds," the researcher said. The scientists found that the effective radiation dose was 35.4 millisieverts for a 64-detector row helical scan and 4.4 mSv for a 320-detector row volume scan.

SOURCE: HealthDay News, Feb. 2010.

Return to top

 
 
 Migraine & Multiple Sclerosis !

Migraine Tied To Raised Multiple Sclerosis Risk

Migraines are more common in women with multiple sclerosis (MS) than in those without the disease, new research shows. The study looked at close to 117,000 U.S. women participating in the Nurses' Health Study II, including 18,000 who had been diagnosed with migraine at the start of the study. The women were assessed every two years over a 16-year period. Of the 375 women who developed MS during the study, 82 had been diagnosed with migraine when the study began. The researchers determined that women with a migraine diagnosis at the start of the study were 47 percent more likely to develop MS than other women. The risk was the same regardless of age, vitamin D levels, body mass index, smoking status or where the women lived. This is the first large-scale study of its kind to examine the association between migraine and MS. "While having a history of migraine diagnosis was linked to MS, women with migraine need to know that over 99 percent of them will never develop MS, thus having migraine should definitely not be a reason to worry about getting MS," according to the study author of the New York University School of Medicine, said in a news release from the American Academy of Neurology.

SOURCE: HealthDay News, Feb. 2010.

Return to top

 
 
 Chest Pain Test !

Quick Chest Pain Test Simplifies Discharge Decision

A simple, inexpensive test can tell doctors whether it's safe to discharge a patient who has come to the emergency room with chest pain, a new study shows. The coronary artery calcium scoring (CACS) test detects coronary artery disease. A CT scan is used to quickly provide doctors with a detailed image of the heart that shows calcium build-up in the coronary arteries. This study of 1,031 chest pain patients found that those with a CACS score of zero can be safely sent home without further heart testing. Of the patients in the study, 61 percent had a CACS of zero. "It is imperative to accurately diagnose patients who come to the emergency department with chest pain. Unfortunately, diagnosing chest pain is often expensive and time-consuming. This new data could save millions of health-care dollars and countless hours spent waiting on unnecessary tests," according to the principal investigator, a cardiologist at the Methodist DeBakey Heart & Vascular Institute in Houston.

SOURCE: HealthDay News, February 2010.

Return to top

 
 
 B-Vitamins Help !

B-Vitamins Help Protect Against Stroke, Heart Disease

People who eat a diet high in B-vitamins are less likely to die from cardiovascular disease, say Japanese researchers. They analyzed dietary questionnaires completed by more than 23,000 men and almost 36,000 women who were part of the Japan Collaborative Cohort Study. During a median 14 years of follow-up, 986 of the people died from stroke, 424 from heart disease, and 2,087 from all diseases related to the cardiovascular system. The study found that women who ate more foods with the B-vitamins folate and B-6 were less likely to die from stroke and heart disease, while men who ate a diet high in these B-vitamins were less likely to die of heart failure. Vitamin B-12 intake was not associated with reduced risk of death from cardiovascular disease. The researchers believe that folate and vitamin B-6 may help protect against cardiovascular disease by lowering levels of homocysteine, an amino acid in the blood that's affected by diet and heredity. Previous research suggests that too much homocysteine may damage the inner lining of arteries and promote the formation of blood clots. Fish, liver, meats, whole grains and fortified cereals are sources of vitamin B-6, while vegetables and fruits, whole or enriched grains, fortified cereals, beans and legumes are sources of folate.

SOURCE: HealthDay News, April, 2010.

Return to top

 
 
 Overactive Thyroid & Stroke !

Overactive Thyroid Linked To Stroke In Young Adults

Young adults who have an overactive thyroid face a much greater risk of stroke than people without the condition, Taiwanese researchers report. "This is a well-controlled analysis, and patients with hyperthyroidism should receive prompt treatment to prevent these complications”, the director of stroke services at the University of Massachusetts in Worcester said. For the study, researchers collected data on 3,176 young adults with hyperthyroidism from the School of Health Care Administration in the College of Medicine at Taipei Medical University. They compared these people with 25,408 similar people who did not have hyperthyroidism. The average age was 32. The researchers followed the patients for five years. During that time, 198 people suffered a stroke, including 31 of patients with hyperthyroidism and 167  without it, the researchers found. After taking into account factors such as age, sex, income, environment, high blood pressure, diabetes, an irregular heart rhythm called atrial fibrillation, high cholesterol, coronary heart disease and whether they were taking medication to treat heart rhythm problems, the risk of having a stroke was 44 percent higher for patients with hyperthyroidism than for those without it, the research team found. "Our study shows an association between hyperthyroidism and the risk of subsequent ischemic stroke in young adults," the scientist said. "A more thorough evaluation in future studies may help elucidate the causes of stroke in this age group. Our results indicate a need for thyroid function testing and detection of hyperthyroidism in surveys to identify the causes of ischemic stroke in young people”, he added. In older adults, hyperthyroidism is associated with atrial fibrillation, which can lead to stroke or sudden cardiac death. However, this relationship has not been documented in younger adults, the researcher said. Treating the hyperthyroidism would probably eliminate the risk factors associated with the risk of a stroke, the scientist added.

SOURCE: HealthDay News, April, 2010.

Return to top

 
 

New Products of SQUARE Pharmaceuticals Ltd.

  Product Neurolin®
  Generic Name Pregabalin
  Strength 50 & 150 mg
  Dosage form Capsule
  Therapeutic Category Antiepileptic
  Product Promtil®  
Generic Name

Prochlorperazine Maleate

Strength

5 mg

Dosage form Tablet
Therapeutic Category Antiemetics & Antivertigo
  Product Beclomin® HFA
  Generic Name Beclometasone Dipropionate
  Strength 100 & 250 mcg/puff
  Dosage form Inhaler
  Therapeutic Category Inhalant Antiasthmatic

Return to top

 

Copyright © 2010 SQUARE Pharmaceuticals Ltd. All rights reserved.