Perkinor

Trihexyphenidyl Hydrochloride USP
Antiparkinsonism Preparation (CNS Preparations)

Indication:
Trihexyphenidyl Hydrochloride is indicated as an adjunct in the treatment of all forms
of parkinsonism (post encephalitic, arteriosclerotic and idiopathic). It is often useful
as adjuvant therapy when treating these forms of parkinsonism with Levodopa.
Additionally, it is indicated for the control of extrapyramidal disorders caused by
some drugs such as Dibenzoxazepines, Phenothiazine, Thioxanthenes and
Butyrophenones.

Dosage & Administration:
Dosage should be individualized. The initial dose should be low and then increased
gradually. Should be taken with food. Total daily intake of Trihexyphenidyl
Hydrochloride tablets is tolerated best in divided doses.
Idiopathic Parkinsonism: As initial therapy for parkinsonism, 1 mg of Trihexyphenidyl
hydrochloride in tablet may be administered the first day. The dose may then be
increased by 2 mg increments at intervals of three to five days. Until a total of 6 to 10
mg is given daily.
Drug induced Parkinsonism: Initial therapy 1 mg. The total daily dosage usually ranges
between 5 and 15mg. Subsequent doses may be progressively increased until
satisfactory control is achieved.
Concomitant use with Levodopa: When Trihexyphenidyl is used concomitantly with
levodopa; the usual dose of each may need to be reduced. Careful adjustment is
necessary, depending on the side effects and degree of symptom control. 3 to 6 mg
daily in divided doses is usually adequate.
Concomitant use with other Parasympathetic Inhibitors: The total daily intake of
Trihexyphenidyl Hydrochloride tablets is tolerated best if divided into 3 doses and
taken at mealtimes. High doses (1O mg daily) may be divided into 4 parts, with 3
doses administered at mealtimes and the fourth at bedtime.
Post encephalitic Parkinsonism: usually 12 to 15 mg.

Preparation:
PerkinorTM 2 Tablet: Box containing 30 tablets in Alu-Alu blister pack
PerkinorTM 5 Tablet: Box containing 30 tablets in Alu-Alu blister pack



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