Levothyroxine Sodium
Thyroid Preparation (Other Hormone Preparation)

1. Hypothyroidism - Primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) hypothyroidism and subclinical hypothyroidism.
2. Pituitary TSH Suppression

Dosage & Administration:
Dosing must be individualized and adjustments made based on periodic assessment of the patient’s clinical response and laboratory parameters.

a) Adult Dosage
Initial starting dose: 25-50 mcg/day, with gradual increments in dose at 6-8weekintervals, as needed. The dose is generally adjusted in 12.5-25 mcg increments until the patient with primary hypothyroidism is clinically euthyroid and the serum TSH has normalized.
In patients with severe hypothyroidism: 12.5-25 mcg/day with gradual increment of 25 mcg/ day every 2-4 weeks.
In patients with secondary (pituitary) or tertiary (hypothalamic) hypothyroidism: The dose should be titrated until the patient is clinically euthyroid and the serum free- T4 level is restored to the upper half of the normal range.
For patients older than 50 years or for patients under 50 years of age with underlying cardiac disease: 1.7 mcg/kg/day.

b) Pediatric Dosage
The recommended starting dose is 10-15 mcg/kg/day. In infants with very low (< 5 mcg/dL) or undetectable serumT4 concentrations, the recommended initial starting dose is 50 mcg/day.
Infants and Children
Initial dose is 25 mcg/day with increments of 25 mcg every 2-4 weeks until the desired effect is achieved.

Thyrin®50 Tablet: Box containing 90 tablets.
Thyrin® 25 Tablet: Box containing 90 tablets.

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