Dosage & Administration:
Upper gastrointestinal haemorrhage:
Adult: Intraperitoneal admin: 8 mg in 250 ml of 0.9% sodium chloride inj. alternatively, instill 8 mg in 100 ml of 0.9% sodium chloride solution through a nasogastric tube every hr for 6–8 hr, then every 2 hr for 4–6 hr. Withdraw drug gradually.
Acute hypotensive states:
Adult: Initially, 8-12 mcg/minute, up to 8-30 mcg/minute in refractory shock. Infuse using a solution of 4 mcg/ml in glucose 5%, or sodium chloride 0.9% and glucose 5% at a rate of 2-3 ml/minute. Adjust according to BP response. Average maintenance dose: 0.5-1 ml/minute (2-4 mcg/minute). Infuse via a central venous catheter or into a large vein. Child: Administer at a rate of 2 mcg/minute. Adjust rate according to BP response and perfusion. Elderly: Initial dose should be at low end of dose range.