- syphilis: early syphilis (primary and secondary)
- latent syphilis (except for neurosyphilis and presence of pathological CSF findings)
For the prophylaxis of:
- rheumatic fever (chorea, rheumatic carditis)
- poststreptococcal glomerulonephritis
Dosage & Administration:
For early syphilis-a single dose of 2.4 million units by deep intramuscular injection is given.
In late syphilis-the above dose is given at weekly intervals for a total of 3 doses. Neonates may be given a single intramuscular injection of 50,000 units per kg body weight for the treatment of congenital syphilis provided there is no evidence of infection in the CSF.
For streptococcal infection it is usually given as a single intramuscular dose of 1.2 million units.
Children may be given intramuscular dose of 0.3 million to 0.9 million units according to body weight. To prevent recurrence of acute rheumatic fever 1.2 million units may be given intramuscularly every 4 weeks; doses of 0.6 or 1.2 million units have been recommended for children.
For administration 3-4 ml water for injection is added to the vial of 12 Lac injection or as directed by the physician.