Oral Anti-Acne (Skin Preparations)

IsotrinTM is a retinoid indicated for the treatment of severe recalcitrant nodular acne (resistant to adequate courses of standard therapy with systemic antibacterial and topical therapy) in patients 12 years of age and older.

Dosage & Administration:
The capsules should be taken with food once or twice daily as per required dose.
Adults including adolescents and the elderly: Isotretinoin therapy should be started at a dose of 0.5 mg/kg daily. For most patients, the dose ranges from 0.5-1.0 mg/kg per day. A treatment course of 15-20 weeks is normally sufficient to achieve remission.
Patients with severe renal insu¬fficiency: In patients with severe renal insufficiency, treatment should be started at a lower dose (e.g. 10 mg/day). The dose should then be increased up to 1 mg/kg/day or until the patient is receiving the maximum tolerated dose.
Patients with intolerance: In patients who show severe intolerance to the recommended dose, treatment may be continued at a lower dose with the consequences of a longer therapy duration and a higher risk of relapse. In order to achieve the maximum possible efficacy in these patients, the dose should normally be continued at the highest tolerated dose.
Additional precautions: Patients should not donate blood during therapy and for 1-month following discontinuation of Isotretinoin because of the potential risk to the fetus of a pregnant transfusion recipient.

IsotrinTM 20: Each pack contains 10 liquid flled hard gelatin capsules.

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